Gene conversion in human rearranged immunoglobulin genes
نویسندگان
چکیده
منابع مشابه
V(H) replacement in rearranged immunoglobulin genes.
Examples suggesting that all or part of the V(H) segment of a rearranged V(H)DJ(H) may be replaced by all or part of another V(H) have been appearing since the 1980s. Evidence has been presented of two rather different types of replacement. One of these has gained acceptance and has now been clearly demonstrated to occur. The other, proposed more recently, has not yet gained general acceptance ...
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Gene conversion (GCV), a mechanism mediated by activation-induced cytidine deaminase (AID) is well established as a mechanism of immunoglobulin diversification in a few species. However, definitive evidence of GCV-like events in human immunoglobulin genes is scarce. The lack of evidence of GCV in human rearranged immunoglobulin gene sequences is puzzling given the presence of highly similar ger...
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متن کاملSpecial Issue: Gene Conversion in Duplicated Genes
Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. Several decades later than the discovery of crossing over, gene conversion was first recognized in fungi when non-Mendelian allelic distortion was observed. Gene conversion occurs when a double-strand break is repaired by using homologous sequences in the genome. In meiosis, there is a strong pref...
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ژورنال
عنوان ژورنال: Immunogenetics
سال: 2006
ISSN: 0093-7711,1432-1211
DOI: 10.1007/s00251-006-0113-6